IGF-I induces upregulation of DDR1 collagen receptor in breast cancer cells by suppressing MIR-199a-5p through the PI3K/AKT pathway

Discoidin Domain Receptor 1 (DDR1) is a collagen receptor tyrosine-kinase that contributes to epithelial-to-mesenchymal transition and enhances cancer progression. Our previous data indicate that, in breast cancer cells, DDR1 interacts with IGF-1R and positively modulates IGF-1R expression and biolo...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Matà, Roberta, Palladino, Chiara, Nicolosi, Maria Luisa, Presti, Anna Rita Lo, Malaguarnera, Roberta, Ragusa, Marco, Sciortino, Daniela, Morrione, Andrea, Maggiolini, Marcello, Vella, Veronica, Belfiore, Antonino
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884947/
https://ncbi.nlm.nih.gov/pubmed/26655502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6524
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