Modular transcriptional repertoire and MicroRNA target analyses characterize genomic dysregulation in the thymus of Down syndrome infants

Trisomy 21-driven transcriptional alterations in human thymus were characterized through gene coexpression network (GCN) and miRNA-target analyses. We used whole thymic tissue - obtained at heart surgery from Down syndrome (DS) and karyotipically normal subjects (CT) - and a network-based approach f...

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Pubblicato in:Oncotarget
Autori principali: Moreira-Filho, Carlos Alberto, Bando, Silvia Yumi, Bertonha, Fernanda Bernardi, Silva, Filipi Nascimento, da Fontoura Costa, Luciano, Ferreira, Leandro Rodrigues, Furlanetto, Glaucio, Chacur, Paulo, Zerbini, Maria Claudia Nogueira, Carneiro-Sampaio, Magda
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper: Pathology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884935/
https://ncbi.nlm.nih.gov/pubmed/26848775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7120
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