A De Novo Deletion in the Regulators of Complement Activation Cluster Producing a Hybrid Complement Factor H/Complement Factor H–Related 3 Gene in Atypical Hemolytic Uremic Syndrome

The regulators of complement activation cluster at chromosome 1q32 contains the complement factor H (CFH) and five complement factor H–related (CFHR) genes. This area of the genome arose from several large genomic duplications, and these low-copy repeats can cause genome instability in this region....

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Pubblicato in:J Am Soc Nephrol
Autori principali: Challis, Rachel C., Araujo, Geisilaine S.R., Wong, Edwin K.S., Anderson, Holly E., Awan, Atif, Dorman, Anthony M., Waldron, Mary, Wilson, Valerie, Brocklebank, Vicky, Strain, Lisa, Morgan, B. Paul, Harris, Claire L., Marchbank, Kevin J., Goodship, Timothy H.J., Kavanagh, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2016
Soggetti:
Brief Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884102/
https://ncbi.nlm.nih.gov/pubmed/26490391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015010100
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