Multi-Center Randomized Phase II Study Comparing Cediranib plus Gefitinib with Cediranib plus Placebo in Subjects with Recurrent/Progressive Glioblastoma

BACKGROUND: Cediranib, an oral pan-vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor, failed to show benefit over lomustine in relapsed glioblastoma. One resistance mechanism for cediranib is up-regulation of epidermal growth factor receptor (EGFR). This study aimed to det...

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Sparad:
Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Brown, Nicholas, McBain, Catherine, Nash, Stephen, Hopkins, Kirsten, Sanghera, Paul, Saran, Frank, Phillips, Mark, Dungey, Fiona, Clifton-Hadley, Laura, Wanek, Katharina, Krell, Daniel, Jeffries, Sarah, Khan, Iftekhar, Smith, Paul, Mulholland, Paul
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2016
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4883746/
https://ncbi.nlm.nih.gov/pubmed/27232884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0156369
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