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Harnessing redox cross-reactivity to profile distinct cysteine modifications

Cysteine S-nitrosation and S-sulfination are naturally occurring post-translational modifications (PTMs) on proteins induced by physiological signals and redox stress. Here we demonstrate that sulfinic acids and nitrosothiols react to form a stable thiosulfonate bond, and leverage this reactivity us...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:J Am Chem Soc
Päätekijät: Majmudar, Jaimeen D., Konopko, Aaron M., Labby, Kristin J., Tom, Christopher T.M.B., Crellin, John E., Prakash, Ashesh, Martin, Brent R.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4883004/
https://ncbi.nlm.nih.gov/pubmed/26780921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b06806
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