A novel transgenic rabbit model with reduced repolarization reserve: long QT syndrome caused by a dominant‐negative mutation of the KCNE1 gene

BACKGROUND AND PURPOSE: The reliable assessment of proarrhythmic risk of compounds under development remains an elusive goal. Current safety guidelines focus on the effects of blocking the KCNH2/HERG ion channel‐in tissues and animals with intact repolarization. Novel models with better predictive v...

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Publicado no:Br J Pharmacol
Main Authors: Major, Péter, Baczkó, István, Hiripi, László, Odening, Katja E., Juhász, Viktor, Kohajda, Zsófia, Horváth, András, Seprényi, György, Kovács, Mária, Virág, László, Jost, Norbert, Prorok, János, Ördög, Balázs, Doleschall, Zoltán, Nattel, Stanley, Varró, András, Bősze, Zsuzsanna
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882500/
https://ncbi.nlm.nih.gov/pubmed/27076034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13500
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