The Small C-terminal Domain Phosphatase 1 Inhibits Cancer Cell Migration and Invasion by Dephosphorylating Ser(P)(68)-Twist1 to Accelerate Twist1 Protein Degradation

Twist1 is a basic helix-loop-helix transcription factor that strongly promotes epithelial-to-mesenchymal transition, migration, invasion, and metastasis of cancer cells. The MAPK-phosphorylated Twist1 on its serine 68 (Ser(P)(68)-Twist1) has a significantly enhanced stability and function to drive c...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Sun, Tong, Fu, Junjiang, Shen, Tao, Lin, Xia, Liao, Lan, Feng, Xin-Hua, Xu, Jianming
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2016
Gaiak:
Gene Regulation
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882423/
https://ncbi.nlm.nih.gov/pubmed/26975371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.721795
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