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Enzymatically modified LDL promotes foam cell formation in smooth muscle cells via macropinocytosis and enhances receptor mediated uptake of oxidized LDL
OBJECTIVE: Enzyme-modified LDL (ELDL) is present in human atherosclerotic lesions. Our objective is to understand the mechanisms of ELDL uptake and its effects on vascular smooth muscle cells. APPROACH AND RESULTS: Transformation of murine aortic SMC into foam cells in response to ELDL was analyzed....
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| Publié dans: | Arterioscler Thromb Vasc Biol |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4882225/ https://ncbi.nlm.nih.gov/pubmed/27079883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.307306 |
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