Enhanced GABA transmission drives bradykinesia following loss of dopamine D2 receptor signaling

Bradykinesia is a prominent phenotype of Parkinson’s disease, depression, and other neurological conditions. Disruption of dopamine transmission plays an important role but progress in understanding the exact mechanisms driving slowness of movement has been impeded due to the heterogeneity of DA rec...

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Gepubliceerd in:Neuron
Hoofdauteurs: Lemos, Julia C., Friend, Danielle M., Kaplan, Alanna R., Shin, Jung Hoon, Rubinstein, Marcelo, Kravitz, Alexxai V., Alvarez, Veronica A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882167/
https://ncbi.nlm.nih.gov/pubmed/27196975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2016.04.040
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