Suppression of USP18 Potentiates the Anti-HBV Activity of Interferon Alpha in HepG2.2.15 Cells via JAK/STAT Signaling

Ubiquitin-specific protease 18 (USP18, also known as UBP43) has both interferon stimulated gene 15 (ISG15) dependent and ISG15-independent functions. By silencing the expression of USP18 in HepG2.2.15 cells, we studied the effect of USP18 on the anti-HBV activity of IFN-α and demonstrated that knock...

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Bibliographic Details
Published in:PLoS One
Main Authors: Li, Lin, Lei, Qing-song, Zhang, Shu-Jun, Kong, Ling-na, Qin, Bo
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882066/
https://ncbi.nlm.nih.gov/pubmed/27227879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0156496
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