Heterogeneity of Human Neutrophil CD177 Expression Results from CD177P1 Pseudogene Conversion

Most humans harbor both CD177(neg) and CD177(pos) neutrophils but 1–10% of people are CD177(null), placing them at risk for formation of anti-neutrophil antibodies that can cause transfusion-related acute lung injury and neonatal alloimmune neutropenia. By deep sequencing the CD177 locus, we catalog...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Wu, Zuopeng, Liang, Rong, Ohnesorg, Thomas, Cho, Vicky, Lam, Wesley, Abhayaratna, Walter P., Gatenby, Paul A., Perera, Chandima, Zhang, Yafei, Whittle, Belinda, Sinclair, Andrew, Goodnow, Christopher C., Field, Matthew, Andrews, T. Daniel, Cook, Matthew C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882059/
https://ncbi.nlm.nih.gov/pubmed/27227454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006067
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