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Gene Transfer of Brain-derived Neurotrophic Factor (BDNF) Prevents Neurodegeneration Triggered by FXN Deficiency

Friedreich's ataxia is a predominantly neurodegenerative disease caused by recessive mutations that produce a deficiency of frataxin (FXN). Here, we have used a herpesviral amplicon vector carrying a gene encoding for brain-derived neurotrophic factor (BDNF) to drive its overexpression in neuro...

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Bibliografiske detaljer
Udgivet i:Mol Ther
Main Authors: Katsu-Jiménez, Yurika, Loría, Frida, Corona, Juan Carlos, Díaz-Nido, Javier
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4881769/
https://ncbi.nlm.nih.gov/pubmed/26849417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.32
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