Reducing IRF-1 to Levels Observed in HESN Subjects Limits HIV Replication, But Not the Extent of Host Immune Activation

Cells from women who are epidemiologically deemed resistant to HIV infection exhibit a 40–60% reduction in endogenous IRF-1 (interferon regulatory factor-1), an essential regulator of host antiviral immunity and the early HIV replication. This study examined the functional consequences of reducing e...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Su, Ruey-Chyi, Plesniarski, Andrew, Ao, Zhujun, Kimani, Joshua, Sivro, Aida, Jaoko, Walter, Plummer, Frank A, Yao, Xiaojian, Ball, Terry Blake
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4881757/
https://ncbi.nlm.nih.gov/pubmed/26506037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2015.29
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