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Cell and Signal Components of the Microenvironment of Bone Metastasis Are Affected by Hypoxia

Bone metastatic cells release bone microenvironment proteins, such as the matricellular protein SPARC (secreted protein acidic and rich in cysteine), and share a cell signaling typical of the bone metabolism controlled by Runx2. The megakaryocytes in the bone marrow engrafted by the metastases seem...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Bendinelli, Paola, Maroni, Paola, Matteucci, Emanuela, Desiderio, Maria Alfonsina
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4881528/
https://ncbi.nlm.nih.gov/pubmed/27187355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17050706
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