A 36-base-pair core sequence of locus control region enhances retrovirally transferred human beta-globin gene expression.
The locus control region of the human beta-globin cluster consists of four major DNase I hypersensitive sites (HS). When linked to globin genes, the locus control region confers a high level of erythroid-specific expression of these genes in transgenic mice or transfected erythroid cell lines. We ha...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
1992
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48813/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1557419/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.7.3107 |
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