A 36-base-pair core sequence of locus control region enhances retrovirally transferred human beta-globin gene expression.

The locus control region of the human beta-globin cluster consists of four major DNase I hypersensitive sites (HS). When linked to globin genes, the locus control region confers a high level of erythroid-specific expression of these genes in transgenic mice or transfected erythroid cell lines. We ha...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Chang, J C, Liu, D, Kan, Y W
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1992
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48813/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1557419/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.7.3107
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