Chromosome Compaction by Active Loop Extrusion

During cell division, chromosomes are compacted in length by more than a 100-fold. A wide range of experiments demonstrated that in their compacted state, mammalian chromosomes form arrays of closely stacked consecutive ∼100 kb loops. The mechanism underlying the active process of chromosome compact...

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Bibliographic Details
Published in:Biophys J
Main Authors: Goloborodko, Anton, Marko, John F., Mirny, Leonid A.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2016
Subjects:
Nucleic Acids and Genome Biophysics Proteins
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4880799/
https://ncbi.nlm.nih.gov/pubmed/27224481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.02.041
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