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The stress regulator FKBP51 drives chronic pain by modulating spinal glucocorticoid signaling

Polymorphisms in FKBP51 are associated with stress-related psychiatric disorders and influence the severity of pain symptoms experienced after trauma. Here, we report that FKBP51 (FK506 binding protein 51) is crucial for the full development and maintenance of long-term pain states and that this is...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Transl Med
Päätekijät: Maiarù, Maria, Tochiki, Keri K., Cox, Marc B., Annan, Leonette V., Bell, Christopher G., Feng, Xixi, Hausch, Felix, Géranton, Sandrine M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4880036/
https://ncbi.nlm.nih.gov/pubmed/26865567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aab3376
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