Daunorubicin-Loaded DNA Origami Nanostructures Circumvent Drug Resistance Mechanisms in a Leukemia Model

Many cancers show primary or acquired drug resistance due to the overexpression of efflux pumps. A novel mechanism to circumvent this is to integrate drugs, such as anthracycline antibiotics, with nanoparticle delivery vehicles that can bypass intrinsic tumor drug-resistance mechanisms. DNA nanopart...

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Veröffentlicht in:Small
Hauptverfasser: Halley, Patrick D., Lucas, Christopher R., McWilliams, Emily M., Webber, Matthew J., Patton, Randy A., Kural, Comert, Lucas, David M., Byrd, John C., Castro, Carlos E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879968/
https://ncbi.nlm.nih.gov/pubmed/26583570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/smll.201502118
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