Genetic Markers of Toxicity From Capecitabine and Other Fluorouracil-Based Regimens: Investigation in the QUASAR2 Study, Systematic Review, and Meta-Analysis

PURPOSE: Fluourouracil (FU) is a mainstay of chemotherapy, although toxicities are common. Genetic biomarkers have been used to predict these adverse events, but their utility is uncertain. PATIENTS AND METHODS: We tested candidate polymorphisms identified from a systematic literature search for ass...

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Publié dans:J Clin Oncol
Auteurs principaux: Rosmarin, Dan, Palles, Claire, Church, David, Domingo, Enric, Jones, Angela, Johnstone, Elaine, Wang, Haitao, Love, Sharon, Julier, Patrick, Scudder, Claire, Nicholson, George, Gonzalez-Neira, Anna, Martin, Miguel, Sargent, Daniel, Green, Erin, McLeod, Howard, Zanger, Ulrich M., Schwab, Matthias, Braun, Michael, Seymour, Matthew, Thompson, Lindsay, Lacas, Benjamin, Boige, Valérie, Ribelles, Nuria, Afzal, Shoaib, Enghusen, Henrik, Jensen, Søren Astrup, Etienne-Grimaldi, Marie-Christine, Milano, Gérard, Wadelius, Mia, Glimelius, Bengt, Garmo, Hans, Gusella, Milena, Lecomte, Thierry, Laurent-Puig, Pierre, Martinez-Balibrea, Eva, Sharma, Rohini, Garcia-Foncillas, Jesus, Kleibl, Zdenek, Morel, Alain, Pignon, Jean-Pierre, Midgley, Rachel, Kerr, David, Tomlinson, Ian
Format: Artigo
Langue:Inglês
Publié: American Society of Clinical Oncology 2014
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ORIGINAL REPORTS
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879695/
https://ncbi.nlm.nih.gov/pubmed/24590654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2013.51.1857
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