C-Reactive Protein Promotes Diabetic Kidney Disease in db/db Mice via the CD32b-Smad3-mTOR signaling Pathway

C-reactive protein (CRP) is associated with progressive diabetic nephropathy in patients with type-2 diabetes (T2DN). However, role of CRP in T2DN remains unclear. We report here that CRP is pathogenic in T2DN in db/db mice that express human CRP (CRPtg-db/db). Compared to the littermate db/db mice,...

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Udgivet i:Sci Rep
Main Authors: You, Yong-Ke, Huang, Xiao-Ru, Chen, Hai-Yong, Lyu, Xia-Fei, Liu, Hua-Feng, Lan, Hui Y.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879671/
https://ncbi.nlm.nih.gov/pubmed/27221338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26740
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