Suramin is an inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcoma cells.

The antitrypanosomal and antifiliarial drug suramin is currently under investigation for treatment of advanced malignancies including prostatic cancer, adrenocortical cancer, and some lymphomas and sarcomas. Here we show that suramin is a potent inhibitor of the nuclear enzyme DNA topoisomerase II....

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Bojanowski, K, Lelievre, S, Markovits, J, Couprie, J, Jacquemin-Sablon, A, Larsen, A K
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48796/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1313577/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.7.3025
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