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Genetic background and epigenetic modifications in the core of the nucleus accumbens predict addiction-like behavior in a rat model

This study provides a demonstration in the rat of a clear genetic difference in the propensity for addiction-related behaviors following prolonged cocaine self-administration. It relies on the use of selectively bred high-responder (bHR) and low-responder (bLR) rat lines that differ in several chara...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Flagel, Shelly B., Chaudhury, Sraboni, Waselus, Maria, Kelly, Rebeca, Sewani, Salima, Clinton, Sarah M., Thompson, Robert C., Watson, Stanley J., Akil, Huda
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878471/
https://ncbi.nlm.nih.gov/pubmed/27114539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520491113
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