The Hypoglycemic Phenotype Is Islet Cell–Autonomous in Short-Chain Hydroxyacyl-CoA Dehydrogenase–Deficient Mice

Congenital hyperinsulinism of infancy (CHI) can be caused by inactivating mutations in the gene encoding short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD), a ubiquitously expressed enzyme involved in fatty acid oxidation. The hypersecretion of insulin may be explained by a loss of interaction betw...

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Bibliografske podrobnosti
izdano v:Diabetes
Main Authors: Molven, Anders, Hollister-Lock, Jennifer, Hu, Jiang, Martinez, Rachael, Njølstad, Pål R., Liew, Chong Wee, Weir, Gordon, Kulkarni, Rohit N.
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2016
Teme:
Islet Studies
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878426/
https://ncbi.nlm.nih.gov/pubmed/26953163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-1475
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