Toll-Like Receptor 2 Mediates In Vivo Pro- and Anti-inflammatory Effects of Mycobacterium Tuberculosis and Modulates Autoimmune Encephalomyelitis

Mycobacteria display pro- and anti-inflammatory effects in human and experimental pathology. We show here that both effects are mediated by Toll-like receptor 2 (Tlr2), by exploiting a previously characterized Tlr2 variant (Met82Ile). Tlr2 82ile promoted self-specific proinflammatory polarization as...

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Vydáno v:Front Immunol
Hlavní autoři: Piermattei, Alessia, Migliara, Giuseppe, Di Sante, Gabriele, Foti, Maria, Hayrabedyan, Soren Bohos, Papagna, Angela, Geloso, Maria Concetta, Corbi, Maddalena, Valentini, Mariagrazia, Sgambato, Alessandro, Delogu, Giovanni, Constantin, Gabriela, Ria, Francesco
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2016
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878199/
https://ncbi.nlm.nih.gov/pubmed/27252700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00191
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