Structural analogs of pulmonary surfactant phosphatidylglycerol inhibit toll-like receptor 2 and 4 signaling

The pulmonary surfactant phospholipid, 1-palmitoyl-2-oleoylphosphatidylglycerol (POPG), potently inhibits toll-like receptor (TLR)2 and TLR4 signaling from the cell surface of macrophages. Analogs of POPG that vary in polar head group length, hydroxylation, and alkyl branching were synthesized using...

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Detalles Bibliográficos
Publicado en:J Lipid Res
Autores principales: Kandasamy, Pitchaimani, Numata, Mari, Berry, Karin Zemski, Fickes, Rachel, Leslie, Christina C., Murphy, Robert C., Voelker, Dennis R.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2016
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878184/
https://ncbi.nlm.nih.gov/pubmed/27095543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M065201
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