Lipotoxic brain microvascular injury is mediated by activating transcription factor 3-dependent inflammatory and oxidative stress pathways

Dysfunction of the cerebrovasculature plays an important role in vascular cognitive impairment (VCI). Lipotoxic injury of the systemic endothelium in response to hydrolyzed triglyceride-rich lipoproteins (TGRLs; TGRL lipolysis products) or a high-fat Western diet (WD) suggests similar mechanisms may...

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Détails bibliographiques
Publié dans:J Lipid Res
Auteurs principaux: Aung, Hnin Hnin, Altman, Robin, Nyunt, Tun, Kim, Jeffrey, Nuthikattu, Saivageethi, Budamagunta, Madhu, Voss, John C., Wilson, Dennis, Rutledge, John C., Villablanca, Amparo C.
Format: Artigo
Langue:Inglês
Publié: The American Society for Biochemistry and Molecular Biology 2016
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878181/
https://ncbi.nlm.nih.gov/pubmed/27087439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M061853
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