A mechanistic evaluation of the Syrian hamster embryo cell transformation assay (pH 6.7) and molecular events leading to senescence bypass in SHE cells

The implementation of the Syrian hamster embryo cell transformation assay (SHE CTA) into test batteries and its relevance in predicting carcinogenicity has been long debated. Despite prevalidation studies to ensure reproducibility and minimise the subjective nature of the assay’s endpoint, an underl...

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Vydáno v:Mutat Res Genet Toxicol Environ Mutagen
Hlavní autoři: Pickles, Jessica C., Pant, Kamala, Mcginty, Lisa A., Yasaei, Hemad, Roberts, Terry, Scott, Andrew D., Newbold, Robert F.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4877681/
https://ncbi.nlm.nih.gov/pubmed/27169376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrgentox.2016.04.002
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