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Synergy of AMPA and NMDA Receptor Currents in Dopaminergic Neurons: A Modeling Study

Dopaminergic (DA) neurons display two modes of firing: low-frequency tonic and high-frequency bursts. The high frequency firing within the bursts is attributed to NMDA, but not AMPA receptor activation. In our models of the DA neuron, both biophysical and abstract, the NMDA receptor current can sign...

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Detalhes bibliográficos
Publicado no:Front Comput Neurosci
Main Authors: Zakharov, Denis, Lapish, Christopher, Gutkin, Boris, Kuznetsov, Alexey
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4877376/
https://ncbi.nlm.nih.gov/pubmed/27252643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncom.2016.00048
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