Glucocorticoids Transcriptionally Regulate miR-27b Expression Promoting Body Fat Accumulation Via Suppressing the Browning of White Adipose Tissue

Long-term glucocorticoid (GC) treatment induces central fat accumulation and metabolic dysfunction. We demonstrate that microRNA-27b (miR-27b) plays a central role in the pathogenesis of GC-induced central fat accumulation. Overexpression of miR-27b had the same effects as dexamethasone (DEX) treatm...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Kong, Xiaocen, Yu, Jing, Bi, Jianhua, Qi, Hanmei, Di, Wenjuan, Wu, Lin, Wang, Long, Zha, Juanmin, Lv, Shan, Zhang, Feng, Li, Yan, Hu, Fang, Liu, Feng, Zhou, Hong, Liu, Juan, Ding, Guoxian
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2015
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876791/
https://ncbi.nlm.nih.gov/pubmed/25187367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-0395
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