A CRISPR/Cas9 mediated point mutation in the alpha 6 subunit of the nicotinic acetylcholine receptor confers resistance to spinosad in Drosophila melanogaster

Spinosad, a widely used and economically important insecticide, targets the nicotinic acetylcholine receptor (nAChRs) of the insect nervous system. Several studies have associated loss of function mutations in the insect nAChR α6 subunit with resistance to spinosad, and in the process identified thi...

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Publicado no:Insect Biochem Mol Biol
Main Authors: Zimmer, Christoph T., Garrood, William T., Puinean, A. Mirel, Eckel-Zimmer, Manuela, Williamson, Martin S., Davies, T.G. Emyr, Bass, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876769/
https://ncbi.nlm.nih.gov/pubmed/27117524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ibmb.2016.04.007
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