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A two-state activation mechanism controls the histone methyltransferase Suv39h1
Specialized chromatin domains contribute to nuclear organization and regulation of gene expression. Gene-poor regions are di- and trimethylated at lysine 9 of histone H3 (H3K9me2/3) by the histone methyltransferase, Suv39h1. This enzyme harnesses a positive feedback loop to spread H3K9me2/3 over ext...
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| Publicado no: | Nat Chem Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4876634/ https://ncbi.nlm.nih.gov/pubmed/26807716 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2008 |
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