Honokiol suppresses TNF-α-induced neutrophil adhesion on cerebral endothelial cells by disrupting polyubiquitination and degradation of IκBα

Adhesion molecules expressed on cerebral endothelial cells (ECs) mediate leukocyte recruitment and play a significant role in cerebral inflammation. Increased levels of adhesion molecules on the EC surface induce leukocyte infiltration into inflammatory areas and are thus hallmarkers of inflammation...

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Publicado en:Sci Rep
Main Authors: Chen, Po-Jen, Wang, Yu-Ling, Kuo, Liang-Mou, Lin, Chwan-Fwu, Chen, Chun-Yu, Tsai, Yung-Fong, Shen, Jiann-Jong, Hwang, Tsong-Long
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876378/
https://ncbi.nlm.nih.gov/pubmed/27212040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26554
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