Interferon-γ and Tumor Necrosis Factor-α Polarize Bone Marrow Stromal Cells Uniformly to a Th1 Phenotype

Activated T cells polarize mesenchymal stromal cells (MSCs) to a proinflammatory Th1 phenotype which likely has an important role in amplifying the immune response in the tumor microenvironment. We investigated the role of interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α), two factors...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Jin, Ping, Zhao, Yuanlong, Liu, Hui, Chen, Jinguo, Ren, Jiaqiang, Jin, Jianjian, Bedognetti, Davide, Liu, Shutong, Wang, Ena, Marincola, Francesco, Stroncek, David
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2016
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876328/
https://ncbi.nlm.nih.gov/pubmed/27211104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26345
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