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An 11-base-pair DNA sequence motif apparently unique to the human interleukin 4 gene confers responsiveness to T-cell activation signals.

We have identified a DNA segment that confers responsiveness to antigen stimulation signals on the human interleukin (IL) 4 gene in Jurkat cells. The human IL-4 gene, of 10 kilobases, is composed of four exons and three introns. A cis-acting element (P sequence) resides in the 5' upstream region; no...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Abe, E, De Waal Malefyt, R, Matsuda, I, Arai, K, Arai, N
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48763/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1532661/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.7.2864
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