The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin

INTRODUCTION: Pharmacokinetic outcomes of transporter-mediated drug-drug interactions (TMDDIs) are increasingly being evaluated clinically. The goal of our study was to determine the effects of selective inhibition of multi-drug and toxin extrusion protein 1 (MATE1) using famotidine, on the pharmaco...

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Publicat a:Clin Pharmacokinet
Autors principals: Hibma, Jennifer E., Zur, Arik A., Castro, Richard A., Wittwer, Matthias B., Keizer, Ron J., Yee, Sook Wah, Goswami, Srijib, Stocker, Sophie L., Zhang, Xuexiang, Huang, Yong, Brett, Claire M., Savic, Radojka M., Giacomini, Kathleen M.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876051/
https://ncbi.nlm.nih.gov/pubmed/26597253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-015-0346-3
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