FoxH1 mediates a Grg4 and Smad2 dependent transcriptional switch in Nodal signaling during Xenopus mesoderm development

In the vertebrate blastula and gastrula the Nodal pathway is essential for formation of the primary germ layers and the organizer. Nodal autoregulatory feedback potentiates signaling activity, but mechanisms limiting embryonic Nodal ligand transcription are poorly understood. Here we describe a tran...

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Udgivet i:Dev Biol
Main Authors: Reid, Christine D., Steiner, Aaron B., Yaklichkin, Sergey, Lu, Qun, Wang, Shouwen, Hennessy, Morgan, Kessler, Daniel S.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4875808/
https://ncbi.nlm.nih.gov/pubmed/27085753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2016.04.006
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