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Atomic features of an autoantigen in heparin-induced thrombocytopenia (HIT)

Autoantigen development is poorly understood at the atomic level. Heparin-induced thrombocytopenia (HIT) is an autoimmune thrombotic disorder caused by antibodies to an antigen composed of platelet factor 4 (PF4) and heparin or cellular glycosaminoglycans (GAGs). In solution, PF4 exists as an equili...

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Detalhes bibliográficos
Publicado no:Autoimmun Rev
Main Authors: Cai, Zheng, Zhu, Zhiqiang, Greene, Mark I, Cines, Douglas B
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4875785/
https://ncbi.nlm.nih.gov/pubmed/26970483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.autrev.2016.03.011
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