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The cell nucleus serves as a mechanotransducer of tissue damage-induced inflammation
Tissue damage activates cytosolic phospholipase A(2) (cPLA(2)), releasing arachidonic acid (AA), which is oxidized to proinflammatory eicosanoids by 5-lipoxygenase (5-LOX) on the nuclear envelope. How tissue damage is sensed to activate cPLA(2) is unknown. We investigated this by live imaging in wou...
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| Pubblicato in: | Cell |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4875569/ https://ncbi.nlm.nih.gov/pubmed/27203112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.04.016 |
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