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β-Catenin Stabilization in Skin Fibroblasts Causes Fibrotic Lesions by Preventing Adipocyte Differentiation of the Reticular Dermis

The Wnt/β-catenin pathway plays a central role in epidermal homeostasis and regeneration, but how it affects fibroblast fate decisions is unknown. We investigated the effect of targeted β-catenin stabilization in dermal fibroblasts. Comparative gene expression profiling of stem cell antigen 1(-) (Sc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Invest Dermatol
Hauptverfasser: Mastrogiannaki, Maria, Lichtenberger, Beate M., Reimer, Andreas, Collins, Charlotte A., Driskell, Ryan R., Watt, Fiona M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874948/
https://ncbi.nlm.nih.gov/pubmed/26902921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2016.01.036
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