PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion

The tumor suppressor PTEN restrains cell migration and invasion by a mechanism that is independent of inhibition of the PI3K pathway and decreased activation of the kinase AKT. PREX2, a widely distributed GEF that activates the GTPase RAC1, binds to and inhibits PTEN. We used mouse embryonic fibrobl...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Sci Signal
Huvudupphovsmän: Mense, Sarah M., Barrows, Douglas, Hodakoski, Cindy, Steinbach, Nicole, Schoenfeld, David, Su, William, Hopkins, Benjamin D., Su, Tao, Fine, Barry, Hibshoosh, Hanina, Parsons, Ramon
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874664/
https://ncbi.nlm.nih.gov/pubmed/25829446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005840
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk