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Dissecting mechanisms of mouse embryonic stem cells heterogeneity through a model-based analysis of transcription factor dynamics

Pluripotent mouse embryonic stem cells (mESCs) show heterogeneous expression levels of transcription factors (TFs) involved in pluripotency regulation, among them Nanog and Rex1. The expression of both TFs can change dynamically between states of high and low activity, correlating with the cells...

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Bibliografske podrobnosti
izdano v:J R Soc Interface
Main Authors: Herberg, Maria, Glauche, Ingmar, Zerjatke, Thomas, Winzi, Maria, Buchholz, Frank, Roeder, Ingo
Format: Artigo
Jezik:Inglês
Izdano: The Royal Society 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874438/
https://ncbi.nlm.nih.gov/pubmed/27097654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2016.0167
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