Trim37-deficient mice recapitulate several features of the multi-organ disorder Mulibrey nanism

Mulibrey nanism (MUL) is a rare autosomal recessive multi-organ disorder characterized by severe prenatal-onset growth failure, infertility, cardiopathy, risk for tumors, fatty liver, and type 2 diabetes. MUL is caused by loss-of-function mutations in TRIM37, which encodes an E3 ubiquitin ligase bel...

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Библиографические подробности
Опубликовано в: :Biol Open
Главные авторы: Kettunen, Kaisa M., Karikoski, Riitta, Hämäläinen, Riikka H., Toivonen, Teija T., Antonenkov, Vasily D., Kulesskaya, Natalia, Voikar, Vootele, Hölttä-Vuori, Maarit, Ikonen, Elina, Sainio, Kirsi, Jalanko, Anu, Karlberg, Susann, Karlberg, Niklas, Lipsanen-Nyman, Marita, Toppari, Jorma, Jauhiainen, Matti, Hiltunen, J. Kalervo, Jalanko, Hannu, Lehesjoki, Anna-Elina
Формат: Artigo
Язык:Inglês
Опубликовано: The Company of Biologists Ltd 2016
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874348/
https://ncbi.nlm.nih.gov/pubmed/27044324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.016246
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