Discovery of a Novel Fluorescent Probe for the Sensitive Detection of β-Amyloid Deposits

Here we reported the development of the first photoinduced electron transfer (PeT) probe (1) to directly locate β-amyloid aggregates (Aβ plaques) in the brain without the need of post-washing procedures. The probe showed a high affinity for Aβ aggregates with a K(d) value of 3.5 nM. It is weakly emi...

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Detalhes bibliográficos
Publicado no:Biosens Bioelectron
Main Authors: Ren, Wenming, Xu, Mingming, Liang, Steven H., Xiang, Huaijiang, Tang, Li, Zhang, Minkui, Ding, Dejun, Li, Xin, Zhang, Haiyan, Hu, Youhong
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874256/
https://ncbi.nlm.nih.gov/pubmed/26313423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bios.2015.08.030
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