Increasing brain angiotensin converting enzyme 2 activity decreases anxiety-like behavior in male mice by activating central Mas receptors

Over-activation of brain renin-angiotensin system (RAS) has been implicated in the etiology of anxiety disorders. Angiotensin converting enzyme (ACE2) inhibits RAS activity by converting angiotensin II, the effector peptide of RAS, to angiotensin-(1-7), which activates Mas receptors (MasR). Whether...

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Pubblicato in:Neuropharmacology
Autori principali: Wang, Lei, de Kloet, Annette D., Pati, Dipanwita, Hiller, Helmut, Smith, Justin A., Pioquinto, David J., Ludin, Jacob A., Oh, S. Paul, Katovich, Michael J., Frazier, Charles J., Raizada, Mohan K., Krause, Eric G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873386/
https://ncbi.nlm.nih.gov/pubmed/26767952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2015.12.026
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