PR55α subunit of protein phosphatase 2A supports the tumorigenic and metastatic potential of pancreatic cancer cells by sustaining hyperactive oncogenic signaling

The protein phosphatase 2 (PP2A) holoenzyme consists of a catalytic subunit, a scaffold subunit, and a regulatory subunit. Based on loss of function analysis using PP2A catalytic inhibitors or inhibition via tumor viral antigens, limited studies suggest that PP2A is a putative tumor suppressor. Howe...

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Gepubliceerd in:Cancer Res
Hoofdauteurs: Hein, Ashley L., Seshacharyulu, Parthasarathy, Rachagani, Satyanarayana, Sheinin, Yuri M., Ouellette, Michel M., Ponnusamy, Moorthy P., Mumby, Marc C., Batra, Surinder K., Yan, Ying
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873354/
https://ncbi.nlm.nih.gov/pubmed/26893480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2119
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