The EGF receptor promotes the malignant potential of glioma by regulating amino acid transport system xc(−)

Extracellular free amino acids contribute to the interaction between a tumor and its microenvironment through effects on cellular metabolism and malignant behavior. System xc(−) is composed of xCT and CD98hc subunits and functions as a plasma membrane antiporter for the uptake of extracellular cysti...

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Published in:Cancer Res
Main Authors: Tsuchihashi, Kenji, Okazaki, Shogo, Ohmura, Mitsuyo, Ishikawa, Miyuki, Sampetrean, Oltea, Onishi, Nobuyuki, Wakimoto, Hiroaki, Yoshikawa, Momoko, Seishima, Ryo, Iwasaki, Yoshimi, Morikawa, Takayuki, Abe, Shinya, Takao, Ayumi, Shimizu, Misato, Masuko, Takashi, Nagane, Motoo, Furnari, Frank, Akiyama, Tetsu, Suematsu, Makoto, Baba, Eishi, Akashi, Koichi, Saya, Hideyuki, Nagano, Osamu
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873328/
https://ncbi.nlm.nih.gov/pubmed/26980765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2121
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