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Ion Mobility Spectrometry-Hydrogen Deuterium Exchange Mass Spectrometry of Anions: Part 3. Estimating Surface Area Exposure by Deuterium Uptake

Gas-phase Hydrogen deuterium exchange (HDX), collision cross section (CCS) measurement, and molecular dynamics simulation (MDS) techniques were utilized to develop and compare three methods for estimating the relative surface area exposure of separate peptide chains within bovine insulin ions. Elect...

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Detalhes bibliográficos
Publicado no:J Am Soc Mass Spectrom
Main Authors: Khakinejad, Mahdiar, Kondalaji, Samaneh Ghassabi, Donohoe, Gregory C., Valentine, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872623/
https://ncbi.nlm.nih.gov/pubmed/26620531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13361-015-1305-9
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