Knockout of NMDA-receptors from parvalbumin interneurons sensitizes to schizophrenia-related deficits induced by MK-801

It has been suggested that a functional deficit in NMDA-receptors (NMDARs) on parvalbumin (PV)-positive interneurons (PV-NMDARs) is central to the pathophysiology of schizophrenia. Supportive evidence come from examination of genetically modified mice where the obligatory NMDAR-subunit GluN1 (also k...

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Publicado no:Transl Psychiatry
Main Authors: Bygrave, A M, Masiulis, S, Nicholson, E, Berkemann, M, Barkus, C, Sprengel, R, Harrison, P J, Kullmann, D M, Bannerman, D M, Kätzel, D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872402/
https://ncbi.nlm.nih.gov/pubmed/27070406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2016.44
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