Adjuvant Lapatinib and Trastuzumab for Early Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer: Results From the Randomized Phase III Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization Trial

BACKGROUND: Lapatinib (L) plus trastuzumab (T) improves outcomes for metastatic human epidermal growth factor 2–positive breast cancer and increases the pathologic complete response in the neoadjuvant setting, but their role as adjuvant therapy remains uncertain. METHODS: In the Adjuvant Lapatinib a...

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Pubblicato in:J Clin Oncol
Autori principali: Piccart-Gebhart, Martine, Holmes, Eileen, Baselga, José, de Azambuja, Evandro, Dueck, Amylou C., Viale, Giuseppe, Zujewski, Jo Anne, Goldhirsch, Aron, Armour, Alison, Pritchard, Kathleen I., McCullough, Ann E., Dolci, Stella, McFadden, Eleanor, Holmes, Andrew P., Tonghua, Liu, Eidtmann, Holger, Dinh, Phuong, Di Cosimo, Serena, Harbeck, Nadia, Tjulandin, Sergei, Im, Young-Hyuck, Huang, Chiun-Sheng, Diéras, Véronique, Hillman, David W., Wolff, Antonio C., Jackisch, Christian, Lang, Istvan, Untch, Michael, Smith, Ian, Boyle, Frances, Xu, Binghe, Gomez, Henry, Suter, Thomas, Gelber, Richard D., Perez, Edith A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2016
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ORIGINAL REPORTS
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872016/
https://ncbi.nlm.nih.gov/pubmed/26598744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2015.62.1797
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